|
KMID : 0383820110710050349
|
|
Tuberculosis and Respiratory Diseases
2011 Volume.71 No. 5 p.349 ~ p.354
|
|
|
E6 Oncoprotein Expression in Non-Small Cell Lung Cancer Patients
|
|
Cho Jung-Nam
Yoon So-Yeon
Hyun Dae-Sung
|
|
|
Abstract
|
|
|
Background: Lung cancer is the leading cause of cancer deaths in the world. Human papillomavirus (HPV) infection and E6 oncoprotein expression are known risk factors for the development of non-small cell lung cancer (NSCLC). This study was performed to evaluate the prevalence of HPV 16/18 E6 oncoprotein expression in patients with NSCLC.
Materials and Methods : Immunohistochemical stains of the HPV 16/18 E6 oncoprotein were performed in tumor tissues from 68 patients with NSCLC who underwent curative surgery from March 2006 to November 2008.
Results: The E6 oncoprotein was expressed in 29.4% of patients with NSCLC and a statistical analysis revealed that E6 oncoprotein expression was significantly higher in females (p=0.028), never smokers (p=0.045), and patients with adenocarcinoma (p=0.022) than that in other patients.
Conclusion: The E6 oncoprotein was expressed in 29.4% of patients with NSCLC. Further studies detecting HPV infection and E6 oncoprotein expression in never smoking patients with NSCLC are needed.
|
|
|
KEYWORD
|
|
|
Lung Neoplasms, oncogene protein E6, human papillomavirus type 18
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|